Midland International Airport is the closest aiport to Big Bend National Park. It is owned and operated by the City of Midland and offers commercial service daily to 8 major hubs including: Dallas Love Field, Dallas/Fort Worth (DFW), George Bush International Airport, Houston Hobby Airport, Austin, El Paso, Las Vegas and Albuquerque.

Public transportation is provided by EZ-Rider who provides fixed route service as well as ADA curb to curb service in Midland and Odessa.